Download Angiotensin II Receptor Blockade Physiological and Clinical by Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. PDF

By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)

The dating among angiotensin II and high blood pressure was once confirmed in 1898 while angiotensin II used to be proven to modulate systemic blood strain. Over the intervening a long time, a whole characterization of the renin-angiotensin process (RAS) has been completed, and our realizing of its biochemistry and body structure has ended in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists able to controlling high blood pressure. extra lately, it used to be proven that angiotensin II is secreted inside convinced tissues and that those tissue-specific structures function independently of the systemic RAS. the radical idea that angiotensin II regulates a few cardiovascular methods which are unrelated to blood strain has renewed the curiosity of either simple and medical scientists in angiotensin II. The organization among angiotensin II and cardiac progress, particularly, has indicated that cures at the moment in use for high blood pressure can have direct program to the therapy of center failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg was once convened October 18-20, 1996 to check the scientific and easy facets of angiotensin receptor biology as they practice to high blood pressure and center failure. additionally, the capability therapy of those stipulations utilizing particular angio­ tensin receptor antagonists was once addressed in the context in their fast healing software and destiny potential.

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17. HallJE, Guyton AC, Trippodo NC, Lohmeier TE, McCaa RE, Cowley AW Jr. 1977. Intrarenal control of electrolyte excretion by angiotensin II. Am J Physiol 232:F538-F544. 18. Hollenberg NK, Williams GH, Taub KJ, Ishikawa I, Brown C, Adams OF. 1977. Renal vascular response to interruption of the RAS in nonnal man. Kid Int 12:285-293. 19. Hollenberg NK, Meggs LG, Williams GH, Katz J, Gamic JD, Harrington DP. 1981. Sodium intake and renal responses to captopril in nonnal man and essential hypertension.

2. Edited by JH Laragh and BM Brenner, 1837-1856. New York: Raven Press. 23. Hopkins PN, Lifton RP, Hollenberg NK, Jeunemaitre X, Hallouin M-C, Skuppin J, Williams CS, Dluhy RG, Lalouel J-M, Williams RR, Williams GH. 1996. Blunted renovascular response to Ang II is associated with a common variant of the AGT gene and obesity. J Hypertens 14:199-207. 24. Jeunemaitre X, Soubrier F, Koeletsey YV, Lifton RP, Williams CS, Caru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, Corvol P. 1992. Molecular basis of human hypertension: role of AGT.

Angiotensinogen, detected immunocytochemically, is predominantly located in astrocytes and ependymal cells [20], and angiotensinogen mRNA detected by in situ hybridization is localized mainly in astrocytes [21]. However, angiotensinogen immunoreactive neurons have also been identified [22], and the presence of angiotensinogen has been demonstrated in CSF as well [23]. The site of synthesis of brain angiotensins is as yet unresolved. Bunnemann et al. [21] suggested that angiotensinogen may be produced in astrocytes and converted to Ang I by renin in the extracellular fluid or alternatively may be taken up by neurons and converted intraneuronally.

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